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Temporary Employment 2 years with option of extension
Your Responsibilities
The fellow will be part of a team led by Key Researcher Dr. Renate Schreiber in the Division of Biochemistry at the Institute of Molecular Biosciences at the University of Graz, Austria. The successful fellow will be working in a multidisciplinary team of basic and clinical scientists within the Cluster of Excellence “MetAGE” focused on improving our molecular understanding of pathophysiology of aging-associated metabolic disorders with a special focus on adipose tissue metabolism.
Establishment of flux analysis using stable isotopes, using microsurgery techniques and GC/MS analyses
Independent planning, implementation and evaluation of scientific experiments
Active participation at regular internal and external meetings as well as (inter)national conferences
Publication in internationally renowned peer-reviewed journals
Co-supervision/mentoring of students working on Bachelor’s, Master’s, or PhD level
Your Profile
Completed doctoral degree/PhD in the area of life sciences or natural sciences
Solid expertise in multidisciplinary techniques including (analytical) biochemistry, molecular biology, mammalian cell culture, working with mouse models (including mouse genetics, physiology, and preferentially surgery techniques)
The candidate shall be able to handle multiple projects simultaneously, work independently, and collaborate within a team
High level of commitment, personal responsibility, and self-motivation for scientific work
Strong communication and social skills
Fluent in written and spoken English
The following documents are required for a complete application:
Motivation letter,
Academic CV including abstract of your PhD Thesis
Proof of completion of the required degree as stated in the job posting
Two recommendation letters, which must be sent directly by the refeeres to [email protected] until the application deadline
HEARING 23th June 2025 in Graz
Project description:
Background: Aging is associated with the pathogenesis of several metabolic diseases such as type 2 diabetes and obesity, but also cachexia which includes the loss of both muscle and fat mass. Both obesity and cachexia are characterized by a dysfunctional adipose tissue which leads to an unintended overflow of lipids toward non-adipose tissues. Accumulation of various lipid species in non-adipose tissues such as muscle or liver may cause tissue dysfunction – a process also termed lipotoxicity. The key process controlling the release of lipids from the adipocyte is termed lipolysis and is mediated primarily via the two enzymes adipose triglyceride lipase and hormone-sensitive lipase [1,2]. How aging and various interventions affect adipocyte lipolysis to reduce aging-associated metabolic disorders is still insufficiently understood and remains controversial [3,4].
Hypothesis and Objectives: We hypothesize that fasting interventions like time-restricted feeding prevent the aging-associated decline of lipid handling in the adipocyte in mice and men. We aim to assess lipid turnover using stable isotope tracer technology [5].
Methodology: To address this question, explorative studies will be performed in mice during circadian cycles of fasting and refeeding and upon fasting intervention. Flux analyses using stable isotopes will allow to quantify lipid metabolism in vivo. State-of-the-art whole-body phenotyping will be applied to assess energy and lipid metabolism (i.e., indirect calorimetry, glucose/insulin tolerance tests). Adipocyte lipolysis will also be determined on a functional, molecular, and biochemical level in mouse tissues, human biopsies, and isolated adipocytes.
References:
1. Zechner, R., Madeo, F. & Kratky, D. Cytosolic lipolysis and lipophagy: Two sides of the same coin. Nat. Rev. Mol. Cell Biol. 18, 671–684 (2017).
2. Schreiber, R., Xie, H. & Schweiger, M. Of mice and men: The physiological role of adipose triglyceride lipase (ATGL). Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1864, 880–899 (2019).
3. Klein, S., Young, V. R., Blackburn, G. L., Bistrian, B. R. & Wolfe, R. R. Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects. J. Clin. Invest. 78, 928–933 (1986).
4. Gao, H. et al. Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation. Cell Metab. 32, 1–3 (2020).
5. Kim, I.-Y., Park, S., Jang, J. & Wolfe, R. R. Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology. J. id Kinetics In Vivo Using Stable Isotope Tracer Methodology. J. Lipid Atheroscler. 9, 110 (2020).
We offer an annual gross salary of € 69,060.59 for a fulltime position.
We Offer
Meaning: We offer meaningful work for the world of tomorrow.
Our internal continuing education program is as colorful as the university itself.
Collaboration: With us, you'll find interdisciplinary, cross-professional opportunities to work together.
Benefits: Of course, there are all the usual benefits, from A "access to healthcare services" to Z "Zero emission goal".
Diversity: Besides our various scientific fields and their related issues, we offer a working environment in which diversity is lived.
Flexibility: We demonstrate flexibility not only with the various working time models but also through the offers for the compatibility of family and career.
About us
At the University of Graz, 4700 employees work together on future questions and solutions for the world of tomorrow. Our students and researchers take on the major challenges of society and share their knowledge. We work for tomorrow. Be part of it!
The University of Graz strives to increase the proportion of women in particular in management and faculty positions and therefore encourages qualified women to apply. In the event of underrepresentation, women with equal qualifications are generally given priority for admission. We welcome applications from persons with disabilities who meet the requirements of the advertised position.
Please note that in order to comply with the applicable data protection regulations, we can only accept applications via our web-based applicant tool for this vacant position.
We work for tomorrow. Join us!
Dettagli del lavoro
Titolo
MetAGE Postdoctoral position: Lipid turnover upon aging (m/w/d)
Choosing the right university can be a challenging decision in a researcher's career. At the University of Graz, this choice is made easier by a unique combi...
