Aix-Marseille Université

Three-year PhD position in Development of interactive expert software stratifying the risk of lung cancer diagnosis in the setting of lung cancer screening based on mathematical modeling and machine learning approaches (funded by A*Midex)

2024-06-20 (Europe/Paris)
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RESEARCHER PROFILE: PhD/ R1: First stage Researcher             

RESEARCH FIELD(S)1: Mathematics / Computer science / Engineering

MAIN SUB RESEARCH FIELD OR DISCIPLINES1: Medical sciences, Information sciences, Psychological sciences

JOB /OFFER DESCRIPTION 

COMPO Team

The ambition of the COMPO Inria-Inserm joint project-team is to develop novel mathematical models integrating data available in clinical oncology (from clinical trials and routine care), in order to provide decision-making tools to medical oncologists, thoracic surgeons and preventive oncology staff. The main goals are: 1) to develop personalized medicine and 2) to optimize the design of scheduling regimen for combinatorial clinical trials. To achieve these, the team uniquely gathers mathematicians, pharmacologists, medical oncologists and surgeons. It is integrated in the Center of Cancer Research of Marseille (Inserm U1068, CNRS UMR7258, Aix-Marseille Université UM105, Institut Paoli-Calmettes) and located in the La Timone Health Science campus of the University Hospitals of Marseille (AP-HM), close to the INCa-labeled center for early phase clinical trials (CLIP2). This joint project-team, built on strong expertise in mathematical modeling, pharmacometrics and experimental and clinical oncology, is committed to develop novel methodologies combining mechanistic and statistical modeling to be ultimately applied at bedside.

The PhD theme and datasets

The aim of the PhD will be to develop and validate clinically usable predictive and mechanistic models of lung cancer development and recurrence in the setting of lung cancer screening, early stage diagnosis and treatment conceptualized in lung cancer interception. This project builds on already existing databases and ongoing prospective projects integrating high dimension clinical, imaging and biological longitudinal phenotyping. The  PREVALUNG, PREVALUNG ETOILE and PREVALUNG BIOCEPTION are 3 intertwined projects respectively funded by the National Institute against cancer (INCa), Aix-Marseille University Fundation for Excellence (A*midex) and the European commission (PREVAUNG EU, Horizon Europe Program). The PREVALUNG studies are recruiting 2750 participants with 3 rounds of lung cancer screening including baseline and longitudinal multimonal phenotyping.

Further validation will be possible harnessing a real life population based prospective study reporting regional data on lung cancer screening, early diagnosis and multimodal treatments, named DATALUNG PACA. 

Direct mentoring

The PhD student will be mentored by a senior data scientist / mathematician (Pr D Barbolosi) and by a thoracic surgeon (Pr D Boulate, PI of PREVALUNGs and DATALUNG PACA studies).

The Main activities will be:

Review of the literature
Benchmark of existing methods
Development of novel ML algorithms
Application to the data and biological and clinical questions
ML modeling of longitudinal imaging data
Writing scientific publications

Additional activities will be:

Continuous integration / continuous deployment of the code
Data visualization
Statistical reporting to the partners
More info at: Website:  https://team.inria.fr/compo/

TYPE OF CONTRACT: TEMPORARY / JOB STATUS: FULL TIME

APPLICATION DEADLINE: 20/06/2024 08:00 AM

ENVISAGED STARTING DATE: 01/10/2024

ENVISAGED DURATION: 36 months

JOB NOT FUNDED THROUGH AN EU RESEARCH FRAMEWORK PROGRAMME

WORK LOCATION(S): 

  • Computational Oncology (COMPO) Inria – Inserm – Faculté de Pharmacie, Aix-Marseille Université – Campus Timone – 27, boulevard Jean Moulin, 13005 Marseille
  • Department of thoracic surgery – Hôpital Nord – Chemin des Bourrely, 13015 Marseille

WHAT WE OFFER:

A three-year PhD contract with the following salary: 
Gross Salary per month: 2 100 € in 2024 
Gross Salary per month: 2 200 € in 2025
Gross Salary per month: 2 300 € in 2026 and onward 

Additional information: The Euraxess Center of Aix-Marseille Université informs foreign visiting professors, researchers, postdoc and PhD candidates about the administrative steps to be undertaken prior to arrival at AMU and the various practical formalities to be completed once in France: visas and entry requirements, insurance, help finding accommodation, support in opening a bank account, etc. More information on AMU EURAXESS Portal 

QUALIFICATIONS, REQUIRED RESEARCH FIELDS, REQUIRED EDUCATION LEVEL, PROFESSIONAL SKILLS, OTHER RESEARCH REQUIREMENTS  

Excellent programing skills (R/python)
Familiarity with real-world data analysis
Excellent background in statistics
Excellent background in statistical/machine learning
Experience in computer vision is a plus
Strong motivation for medical and societal applications of computational methods
Knowledge of biology and/or medicine is a plus
Ability to work both independently and as a team, good relational skills
French or English speaking
Intermediate academic writing skills
Intermediate oral presentation skills

Soft skills: Autonomy, Teamwork, Analytical and critical thinking, Listening and observing, Empathy, Flexibility and adaptability, Linguistics, communicative and plurilingual, Co-operation, Conflict-resolution. Required languages: French and English.

REQUESTED DOCUMENTS OF APPLICATION, ELIGIBILITY CRITERIA, SELECTION PROCESS

CV and Cover letter
The candidate will be selected based on their CV, cover letter and oral interviews by the mentors and a Laennec Institute jury

HOW TO APPLY: david.boulate@ap-hm.frDominique.barbolosi@univ-amu.frsebastien.benzekry@inria.fr

Candidati

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Dettagli del lavoro

Titolo
Three-year PhD position in Development of interactive expert software stratifying the risk of lung cancer diagnosis in the setting of lung cancer screening based on mathematical modeling and machine learning approaches (funded by A*Midex)
Datore di lavoro
Sede
Jardin du Pharo 58, bd Charles Livon Marsiglia, Francia
Pubblicato
2024-05-03
Scadenza candidatura
2024-06-20 23:59 (Europe/Paris)
2024-06-20 23:59 (CET)
Tipo di lavoro
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